1534939978姐的微信

Find Out the Sexy Secrets of Zachary Levi, Krysta Rodriguez and More in the New Broadway.com Video Series First Date Flirts!

first_img Star Files View Comments First Date Show Closed This production ended its run on Jan. 5, 2014 Related Shows Zachary Levi Ever wanted to know the name of Zachary Levi’s first crush? Dying to find out the wildest place Krysta Rodriguez has kissed someone? Get to know the romantic secrets of all the cast members in Broadway’s hilarious musical comedy First Date with Broadway.com’s brand new video series First Date Flirts!Starting Monday, September 16, we’ll be rolling out exclusive interviews and confessions of the show’s sexy, funny cast members, including Sara Chase, Blake Hammond, Bryce Ryness, Kristoffer Cusick and Kate Loprest.First Date Flirts will give you the lowdown on the cast members’ most horrifying pick-up lines, best excuses for getting out of dates, celebrity crushes, wildest nights out and more! By the time we’re done, you’ll know way more than you ever thought you would about Broadway’s funniest cast of romantics.Tune in to Broadway.com next week for the first episode of First Date Flirts—and get plenty more exclusive First Date video content with Krysta Rodriguez’s backstage video blog Kiss & Tell!last_img read more

0
Read More

Parkinson’s disease biomarker found in patient urine samples

first_imgShare LinkedIn Share on Twitter Pinterest For more than five years, urine and cerebral-spinal fluid samples from patients with Parkinson’s disease have been locked in freezers in the NINDS National Repository, stored with the expectation they might someday help unravel the still-hidden course of this slow-acting neurodegenerative disease.Now, research by Andrew West, Ph.D., and colleagues at the University of Alabama at Birmingham has revealed that the tubes hold a brand-new type of biomarker — a phosphorylated protein that correlates with the presence and severity of Parkinson’s disease. West and colleagues, with support from the National Institutes of Health, the Michael J. Fox Foundation for Parkinson’s Disease Research and the Parkinson’s Disease Foundation, are digging deeper into these biobanked samples, to validate the biomarker as a possible guide for future clinical treatments and a monitor of the efficacy of potential new Parkinson’s drugs in real time during treatment.“Nobody thought we’d be able to measure the activity of this huge protein called LRRK2 (pronounced lark two) in biofluids since it is usually found inside neurons in the brain,” said West, co-director of the Center for Neurodegeneration and Experimental Therapeutics, and the John A. and Ruth R. Jurenko Professor of Neurology at UAB. “New biochemical markers like the one we’ve discovered together with new neuroimaging approaches are going to be the key to successfully stopping Parkinson’s disease in its tracks. I think the days of blindly testing new therapies for complex diseases like Parkinson’s without having active feedback both for ‘on-target’ drug effects and for effectiveness in patients are thankfully coming to an end.”center_img Share on Facebook Email A biomarker helps physicians predict, diagnose or monitor disease, because the biomarker corresponds to the presence or risk of disease, and its levels may change as the disease progresses. Validated biomarkers can aid both preclinical trial work in the laboratory and future clinical trials of drugs to treat Parkinson’s. West and others are paving the way for an inhibitor drug that prevented neuroinflammation and neurodegeneration in an animal model of the disease, as reported last year by West and colleagues.The new biomarker findings were published in Neurology in March and Movement Disorders in June. The biomarker, LRRK2, has been shown to play a role in hereditary Parkinson’s, and the most common of these mutations — called G2019S — causes the LRRK2 kinase to add too many phosphates to itself and other proteins. Why this leads to Parkinson’s disease is not yet clear.The key to West’s biomarker approach was the recognition that LRRK2 can be purified from a new type of vesicle called exosomes found in all human biofluids, like urine and saliva. Cells in the body continually release exosomes that contain a mixture of proteins, RNA and DNA derived from different kinds of cells. West and colleagues were able to purify exosomes from 3- or 4-ounce urine samples donated by patients, and then measure phosphorylated LRRK2 in those exosomes.The findingsIn the Neurology study, they found that elevated phosphorylated LRRK2 predicted the risk for onset of Parkinson’s disease for people carrying a mutation in LRRK2, which is about 2-3 percent of all Parkinson’s disease patients. These findings were first tested with a preliminary, 14-person cohort of urine samples from the Columbia University Movement Disorders Center. That was followed by a larger replication study of 72 biobanked urine samples from the Michael J. Fox Foundation LRRK2 Cohort Consortium. All samples were provided to UAB in a blinded fashion to ensure the approach was rigorous.The follow-up Movement Disorders paper — the first study of its type — expanded the scope to people without LRRK2 mutations, which is most Parkinson’s disease patients. Using 158 urine samples from Parkinson’s disease patients and healthy controls enrolled in the UAB Movement Disorder Clinic as part of the NIH Parkinson’s Disease Biomarker Program, West and colleagues found that approximately 20 percent of people without LRRK2 mutations but with Parkinson’s disease also showed highly elevated phosphorylated LRRK2 similar to people with LRRK2 mutations, and this was not present in healthy controls. The study speculates that people with elevated phosphorylated LRRK2 may be particularly good candidates for future drugs that reduce phosphorylated LRRK2.Next stepsQuestions remain for this evidence of biochemical changes in LRRK2 in idiopathic Parkinson’s disease. One is finding out where the urinary exosomes come from. Given a suspected role for inflammation in Parkinson’s disease, it is interesting that LRRK2 is highly expressed in cells of the innate immune system. A possible explanation for the phosphorylated LRRK2 in patients with more severe disease may be an increased inflammation in those patients who have aggressive progression of disease.In May, West was awarded a new U01 collaborative grant from the National Institute of Neurological Disorders and Stroke to further explore urinary exosomes and extend the observations to cerebral-spinal fluid as a marker for disease prediction and prognosis.last_img read more

0
Read More

Man United after two defenders, one player ‘can leave’ club if…

first_imgThe World Cup winner with France has been struggling with knee problems since the end of the last season and has missed fixtures from last September to February, barring an appearance against Atletico Madrid in November.According to Calciomercato, Manchester United ‘like’ the 25-year-old and Umtiti ‘can leave’ the Spanish champions in the summer, if they decide to bring in Matthijs de Ligt from Ajax in the summer.De Ligt has been heavily linked with a move to Barca and their president Josep Maria Bartomeu has already confirmed his side’s interest in the 19-year-old Dutchman.The France international signed a new contract last June and his current deal at the Camp Nou will expire in 2023.Embed from Getty ImagesAnother report from Calciomercato claims Paris Saint-Germain’s Layvin Kurzawa is ‘targeted’ by the 20-time English champions.The PSG left-back has started in five matches across all competitions this season and has less than 18 months left on his contract at Parc des Princes. The Ligue 1 winners have offered an extension, but his limited playing time may force him to make a move elsewhere.Luke Shaw has established himself as the first choice left-back. Matteo Darmian is expected to leave the Premier League club in the summer and if United sign Kurzawa, the latter can be a back up for the England international at Old Trafford.Whilst both claims do feel somewhat regurgitated, the Umtiti transfer idea could grow. In Spain, the idea of Barca signing De Ligt was first seen as fanciful but is now gaining some concrete claims, and the club will likely need money to fund it.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksTrending TodayForge of Empires – Free Online GameIf You Like to Play, this City-Building Game is a Must-Have. No Install.Forge of Empires – Free Online GameUndoRaid: Shadow Legends | Free DownloadEven Non-Gamers Are Obsessed With This RPG Game (It’s Worth Installing!)Raid: Shadow Legends | Free DownloadUndoDating.comTung Chung is actually full of single men. Check them out on this premium dating site!Dating.comUndoPerfect-Dating.comReveal Tung Chung As The Best City to Date for Love & RomancePerfect-Dating.comUndoKeto减肥1個簡單的妙招一夜「融化」腹部贅肉(今晚試試)Keto减肥UndoCNBC InternationalHere’s How Big Businesses in Singapore Are Managing the Impact of COVID-19.CNBC InternationalUndo熱門話題小心會長過頭…網友推爆:「真的長得超誇張!」熱門話題UndoSingles50Hong Kong: A 40+ Dating Site That Actually Works!Singles50UndoCoworking Space | Search AdsThe cost of shared office in Hong Kong might surprise youCoworking Space | Search AdsUndo Samuel Umtiti has started in only eight league games for Barcelona this season as a knee injury has forced him to spend more time away from the pitch.last_img read more

0
Read More